Comparison of polyclonal induction agents in pediatric renal transplantation
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چکیده
منابع مشابه
Comparison of polyclonal induction agents in pediatric renal transplantation.
Collective pediatric data suggest that anti-T-cell induction therapy with polyclonal antibodies improves the outcome of both short- and long-term renal allograft survival. Polyclonal agents, including thymoglobulin (Thy), a rabbit anti-thymocyte globulin; Minnesota (horse) anti-lymphoblast globulin (ALG); and ATGAM, a horse anti-thymocyte globulin (ATG), all suppress B and T cells. While no spe...
متن کاملAdvances in Pediatric Renal Transplantation
The science of kidney transplantation in children has advanced remarkably in the last 40 years [1, 2]. As kidney transplants in adult recipients were becoming more common with improving shortand long-term outcomes, results in children were lagging behind. This lag was attributed to multiple factors: greater surgical and technical problems in small children, different metabolism for needed drugs...
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BACKGROUND There are few comparisons of antibody induction therapy allowing early glucocorticoid withdrawal in renal-transplant recipients. The purpose of the present study was to compare induction therapy involving alemtuzumab with the most commonly used induction regimens in patient populations at either high immunologic risk or low immunologic risk. METHODS In this prospective study, we ra...
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متن کاملPolyclonal Anti-T Cell Antibodies in Renal Transplantation
Polyclonal anti-T cell antibodies or antilymphocyte serum (ALS) are xenogeneic antihuman polyclonal antibodies, more precisely antithymocyte globulins (ATG). They are prepared by immunizing rabbits or horses with human lymphoid cells derived from the thymus. They were first prepared for clinical use in horses [1] and followed by a more potent preparation in rabbits. Despite some problems of usi...
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ژورنال
عنوان ژورنال: Pediatric Transplantation
سال: 2001
ISSN: 1397-3142,1399-3046
DOI: 10.1034/j.1399-3046.2001.00054.x